[1]勾秋芬,陈封政,封家福*,等.羟基酪醇-β-环糊精包合工艺[J].四川师范大学学报(自然科学版),2018,(04):539-543.[doi:10.3969/j.issn.1001-8395.2018.04.019]
 GOU Qiufen,CHEN Fengzheng,FENG Jiafu,et al.Optimizing the Technology for the Inclusion of Hydroxyltyrosol with β-cyclodextrin[J].Journal of SichuanNormal University,2018,(04):539-543.[doi:10.3969/j.issn.1001-8395.2018.04.019]
点击复制

羟基酪醇-β-环糊精包合工艺()
分享到:

《四川师范大学学报(自然科学版)》[ISSN:1001-8395/CN:51-1295/N]

卷:
期数:
2018年04期
页码:
539-543
栏目:
基础理论
出版日期:
2018-04-15

文章信息/Info

Title:
Optimizing the Technology for the Inclusion of Hydroxyltyrosol with β-cyclodextrin
文章编号:
1001-8395(2018)04-0539-05
作者:
勾秋芬1 陈封政2 封家福1* 任华忠1
1.乐山职业技术学院 药学系, 四川 乐山 614000;
2.乐山师范学院 化学学院, 四川 乐山 614000
Author(s):
GOU Qiufen1 CHEN Fengzheng2 FENG Jiafu1 REN Huazhong1
1.Department of Pharmacy, Leshan Vocational &
Technical College, Leshan 614000, Sichuan;
2.College of Chemistry, Leshan Normal University, Leshan 614000, Sichuan
关键词:
羟基酪醇 β-环糊精 包合技术 稳定性 饱和水溶液法
Keywords:
hydroxyltyrosol β-cyclodextrin inclusion technology stability the saturated solution inclusion method
分类号:
R944.2
DOI:
10.3969/j.issn.1001-8395.2018.04.019
文献标志码:
A
摘要:
利用环糊精包合技术对羟基酪醇进行包合可以提高其稳定性和利用率.通过比较饱和水溶液法、超声法和研磨法3种环糊精包合技术方法,确定最优的包合方法,再结合正交设计优化包合工艺.羟基酪醇β-环糊精包合物最佳包合方法是饱和水溶液法,最佳工艺为:在恒温50 ℃条件下,羟基酪醇体积与β-环糊精的质量比为1:6,搅拌1 h,搅拌速度为1 200 r/min.饱和水溶液法制备羟基酪醇-β-环糊精包合物,方法可行,操作简单,可有效提高羟基酪醇的稳定性.
Abstract:
The stability and the utilization of the hydroxyltyrosol can be improved with the inclusion technology of β-cyclodextrin.The best inclusion method of hydroxyltyrosol with β-cyclodextrin was obtained by comparing the saturated solution inclusion method, the ultrasonic inclusion method, and the grinding inclusion method.And the optimal technological factors were determined by orthogonal experiments.The results indicated that the best inclusion method was the saturated solution inclusion method, and the optimal technological factors were as follows: the ratio of the hydroxyltyrosol volume to the β-cyclodextrin quality was 1:6, the temperature was 50 ℃, and the stirring speed and time were 1 200 r/min and 1 h, respectively.The conclusion was that the saturated solution inclusion method used for the preparation of inclusion compound of hydroxyltyrosol with β-cyclodextrin was simple, feasilble and could effectively improve the stability of hydroxyltyrosol.

参考文献/References:

[1] 金元宝,党建章,代建国,等.橄榄苦苷盐酸水解液中羟基酪醇的纯化[J].江苏农业科学,2012,40(2):208-210.
[2] JEMAI H, BOUAZIZ M, FKI I, et al.Hypolipidimic and antioxidant activities of oleuropein and its hydrolysis derivative-rich extracts from Chemlali olive leaves[J].Chem Biol Interact,2008,176(2/3):88-98.
[3] BISIGNANO G, TOMAINO A, LO CASCIO R, et al.On the in-vitro antimicrobial activity of oleuropein and hydroxytyrnsol[J].J Pharm Pharmacol,1999,51(8):971-974.
[4] RUIZ BARBA J L, GARRIDO FERNSNDEZ A, JIMENEZ DFZA R.Bactericidal action of oleuropein extracted from green olives against Lactobacillus plantarum[J].Lett Appl Microbiol,1991,12(2):65-68.
[5] CAPPSSO R, EVIDENTE A, SCHIVO L, et al.Antibacterial polyphenols from olive oil mill waste waters[J].Appl Bact,1995,79(4):393-398.
[6] AZIZ N H, FARAG S E, MOUSA L A, et al.Comparative antibacterial and antifungal effects of some phenolic compounds[J].Microbios,1998,93(374):43-54.
[7] HASHIM Z H, ROWLAND I R, MCGLYNN H, et al.Inhibitory effects of olive oil phenolics on invasion in human colon adenocarcinoma cells in vitro[J].Int J Cancer,2008,122(3):495-500.
[8] SCHAFFER S, PODSTAWA M, VISIOLI F, et al.Hydroxytyrosol-rich olive mill wastewater extract protects brain cells in vitro and ex vivo[J].J Agric Food Chem,2007,55(13):5043-5049.
[9] AUROMA O I, DELANE M, JENNER A, et al.Effects of hydroxytyosol found in extra virgin olive oil on oxidative DNA damage and on low-density lipoprotein oxidation[J].J Agric Food Chem,1998,46(15):5181-5187.
[10] VISIOLI F, BELLOMO G, MONTEDORO G F, et al.Low-density lipoprotein oxidation is inhibited in vitro by olive oil constituents[J].Atherosclerosis,1995,17(1):25-32.
[11] ZHU L, LIU Z B, FENG Z H, et al.Hydroxytyrosol protects against oxidative damage by simultaneous activation of mitochondrial biogenesis and phase II detoxifying enzyme systems in retinalpigment epithelial cells[J].J Nutr Biochem,2010,21(11):1089-1098.
[12] MASCITELLI L, PEZZETTA F, SULLIVAN J L.The effect of polyphenols in olive oil on heart disease risk factors[J].Ann Intern Med,2007,146(5):333-341.
[13] 张志荣.药剂学[M].北京:高等教育出版社,2007.
[14] 刘志敏.β-环糊精在食品工业中的应用研究进展[J].河南职业技术师范学院学报,1999,27(2):49-52.
[15] 孙芸,燕雪花,葛亮,等.甘草黄酮-β-环糊精包合工艺优化[J].中国实验方剂学杂志,2011,17(4):30-32.
[16] XIE Y D, XU Y H, CHEN Z Z, et al.A new multifunctional hydroxytyrosol-fenofibrate with antidiabetic, antihyperlipidemic, antioxidant and antiinflammatory action[J].Biomedicine & Pharmacotherapy,2017,95:1749-1758.
[17] ZHOU D Y, SUN Y X, SHAHIDI F.Preparation and antioxidant activity of tyrosol and hydroxytyrosol esters[J].J Functional Foods,2017,37:66-73.
[18] COFRADES S, SANTOS-LPEZ J A, FREIRE M, et al.Oxidative stability of meat systems made with W1/O/W2, emulsions prepared with hydroxytyrosol and chia oil as lipid phase[J].LWT - Food Science and Technology,2014,59(2):941-947.
[19] WU H C, JIANG K F, ZHANG T, et al.Hydroxytyrosol exerts an anti-inflammatory effect by suppressing Toll-like receptor 2 and TLR 2 downstream pathways in Staphylococcus aureus-induced mastitis in mice[J].J Functional Foods,2017,35:595-604.
[20] HEMANT P, NIKOLAS L, PANAGIOTIS E, et al.Hydroxytyrosol ameliorates metabolic, cardiovascular and liver changes in a rat model of diet-induced metabolic syndrome:pharmacological and metabolism-based investigation[J].Pharmacological Research,2017,117:32-45.
[21] SILVIA C, STEFANIA D, SERENA G, et al.Hydroxytyrosol prevents chondrocyte death under oxidative stress by inducing autophagy through sirtuin 1-dependent and -independent mechanisms[J].Biochimica et Biophysica Acta(BBA)- General Subjects,2016,1860(6):1181-1191.
[22] LIDIA T, ARBACE O, SERGIO S, et al.The protective role of olive oil hydroxytyrosol against oxidative alterations induced by mercury in human erythrocytes[J].Food and Chemical Toxicology,2015,82:59-63.

备注/Memo

备注/Memo:
收稿日期:2017-04-15 接受日期:2017-07-05
基金项目:四川省高校重点实验室开放基金(10Y201510)和四川省教育厅重大培育项目(14CZ0024)
*通信作者简介:封家福(1977—),男,副教授,主要从事功能性化学成分的研究,E-mail:616738396@qq.com
更新日期/Last Update: 2018-04-15