[1]孟令强,杨绍娟*,张小博.新型喹唑啉类化合物的合成研究[J].四川师范大学学报(自然科学版),2020,43(03):357-363.[doi:10.3969/j.issn.1001-8395.2020.03.011]
 MENG Lingqiang,YANG Shaojuan,ZHANG Xiaobo.Synthesis of Novel Quinazoline Compounds[J].Journal of SichuanNormal University,2020,43(03):357-363.[doi:10.3969/j.issn.1001-8395.2020.03.011]
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新型喹唑啉类化合物的合成研究()
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《四川师范大学学报(自然科学版)》[ISSN:1001-8395/CN:51-1295/N]

卷:
43卷
期数:
2020年03期
页码:
357-363
栏目:
基础理论
出版日期:
2020-05-05

文章信息/Info

Title:
Synthesis of Novel Quinazoline Compounds
文章编号:
1001-8395(2020)03-0357-07
作者:
孟令强1 杨绍娟2* 张小博3
1. 燕京理工学院 教务处, 河北 三河 065201; 2. 燕京理工学院 生命与健康学院, 河北 三河 065201; 3. 燕京理工学院 工学院, 河北 三河 065201
Author(s):
MENG Lingqiang1 YANG Shaojuan2 ZHANG Xiaobo3
1. The Dean's Office, Yanching Institute of Technology, Sanhe 065201, Hebei; 2. School of Life and Health, Yanching Institute of Technology, Sanhe 065201, Hebei; 3. College of Engineering, Yanching Institute of Technology, Sanhe 065201, Hebei
关键词:
2-氨基-4-甲氧基-3-(3-氯丙氧基)苯甲酸甲酯 合成 新型喹唑啉类化合物
Keywords:
2-amino-4-methoxy-3-(3-chloropropoxy)benzoic acid methyl ester synthesis novel quinazoline compounds
分类号:
R914.5
DOI:
10.3969/j.issn.1001-8395.2020.03.011
文献标志码:
A
摘要:
以2-氨基-4-甲氧基-3-(3-氯丙氧基)苯甲酸甲酯为原料,经环合、氯代和取代等反应得到6种新型喹唑啉类化合物,总收率为45%左右; 目标产物结构经GC-MS和核磁1HNMR进行表征.与传统方法相比,该法具有原料廉价易得、路线简短、操作简便和反应条件温和等优点,为后续的生物活性测试打下良好的基础.
Abstract:
Six novel quinazolines were synthesized by the reaction of 2-amino-4-methoxy-3-(3-chloropropoxy)benzoic acid methyl ester by cyclization, chlorination and substitution. The total yield was about 45%. The structure of target products was characterized by GC-MS and 1HNMR. Compared with the traditional method, the method has the advantages of cheap raw materials, short route, easy operation and mild reaction conditions, which laid a good foundation for the subsequent bioactivity test.

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备注/Memo

备注/Memo:
收稿日期:2017-10-31 接受日期:2019-03-28 基金项目:廊坊市科技支撑计划(2017011070) *通信作者简介:杨绍娟(1982-),女,讲师,主要从事药物合成的研究,E-mail:meng830323@163.com
更新日期/Last Update: 2020-05-05